Biomaterials: Engineered meatballs via micro-carriers

Zejun Fan From Dulab won "Youth Excellene Paper Presentation" Award in BME2021-2022.

清华大学医学院杜亚楠研究团队应邀在国际知名学术期刊"细胞生物学进展"（Trends in Cell Biology）发表题为"纤维化进程中的机械通讯"的综述文章。

In this review, we focus on the main crosslinking mechanisms that commonly exist in a plethora of chronic diseases (e.g. fibrosis, cancer, osteoarthritis) and summarize current understandings including the biochemical reaction, the effect on ECM properties, the influence on cellular behaviors, and related studies in disease model establishment.

We developed MSC-laden microcarriers in spinner flask culture as cell delivery vehicles to solve those difficulties in alleviating the progression of osteoarthritis by using exogenous MSC.

We genetically engineered MSCs with Exendin-4 (MSC-Ex-4), a glucagon-like peptide-1 (GLP-1) analog, and demonstrated their boosted cellular functions and antidiabetic efficacy in the type 2 diabetes mellitus (T2DM) mouse model.

We developed the 3D‐MAPS as a platform technology to rapidly fabricate centimeter‐sized functional tissue constructs with complex structures

We demonstrate the different patterns of AYM changes in epithelial and mesenchymal cell types on substrates with different stiffness